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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Human Upgrade: Biohacking for Longevity & Performance

    Meet the Governor Who Wants Humans to Become Cyborgs : 1406

    29.1.2026 | 1 t. 7 min.
    Aging is not something Zoltan Istvan plans to accept quietly. He wants to treat death like a technical bug, rewrite the rules of biology, and turn California into the global test bed for radical human upgrades. From cyborg implants to AI driven longevity science, this episode explores what happens when a candidate for governor openly argues that humans should evolve beyond their biological limits and take control of how long and how well they live.

    Watch this episode on YouTube for the full video experience:
    https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey sits down with Zoltan Istvan, a leading transhumanist, futurist, longevity advocate, and current candidate for Governor of California. Zoltan has spoken at Parliaments and Senates around the world, appeared on The Joe Rogan Experience, consulted for the US Armed Forces, and served as a correspondent for The New York Times. He has addressed the World Bank, the World Economic Forum, and the UK Parliament, and his work has influenced world leaders while shaping global conversations on AI, liberty, and human enhancement. Trained in philosophy and ethics at Columbia University and the University of Oxford, Zoltan brings rare depth to the intersection of technology, biology, and governance.

    Together, they explore whether aging should be classified as a disease, why regulation is slowing breakthroughs in longevity science, and how California could become ground zero for anti-aging innovation. They debate biology versus machine integration, open source technology versus centralized control, and what morphological freedom really means when enhancement technologies move faster than policy. The discussion spans mitochondria, neuroplasticity, brain optimization, stem cells, organ printing, implants, and the ethical risks of surveillance, algorithmic persuasion, and unchecked AI.

    This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, metabolism, functional medicine, anti-aging strategies, supplements, nootropics, ketosis, fasting, carnivore frameworks, sleep optimization, and living Smarter Not Harder in a world increasingly shaped by AI and technology, ideally with a cup of Danger Coffee in hand.

    You’ll Learn:
    • Why aging may be a solvable problem rather than an unavoidable fate
    • How politics and regulation influence access to longevity and anti-aging therapies
    • The real tradeoffs between biological upgrades and machine integration
    • Why mitochondria, neuroplasticity, and brain optimization matter in human enhancement
    • How AI and surveillance technology threaten cognitive and biological autonomy
    • What morphological freedom means for the future of medicine and personal choice
    • Why open source approaches to biohacking could protect liberty and innovation
    • How Smarter Not Harder strategies support longevity in a rapidly evolving world

    Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

    Thank you to our sponsors!
    BEYOND Conference 2026 | Register now with code DAVE300 for $300 off at https://beyondconference.com/
    MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.
    GOT MOLD? | See what’s in your air and save 10% with code DAVE10 at http://gotmold.com/shop
    EMR-Tek | Get 40% off EMF protection with code DAVE at https://www.emr-tek.com/DAVE

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: transhumanism podcast, human cyborg future, biohacking transhumanism, longevity technology podcast, anti-aging technology, human enhancement podcast, cyborg implants future, AI human evolution, aging as a disease, radical longevity science, human performance future, brain optimization technology, mitochondria longevity science, neuroplasticity enhancement, biohacking longevity politics, California longevity policy, morphological freedom body, human augmentation debate, AI risk humanity, surveillance technology health, open source biohacking, stem cell longevity future, organ printing technology, functional medicine future, metabolism longevity science, ketosis fasting longevity, nootropics brain optimization, supplements longevity science, carnivore diet longevity, sleep optimization performance, Dave Asprey transhumanism, Zoltan Istvan podcast, futurist longevity interview, governor cyborg policy, technology immortality debate

    Resources:
    • Learn More About Zoltan’s Work At: https://zoltanistvan.com/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Upgrade Collective: https://www.ourupgradecollective.com
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    0:00 – Introduction
    3:51 – What Is Transhumanism
    8:15 – Biology vs Technology
    12:53 – Government & Regulation
    20:43 – Running for Governor
    26:13 – Social Media & Kids
    30:18 – Life Extension & Upgrades
    38:59 – Defining Humanity
    46:12 – Consciousness & Uploading
    49:27 – Religion & Society
    58:02 – AI Existential Risk
    1:02:57 – Space & Future Enhancement
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Your Butt is a Longevity Organ (Here’s how to train it!) | Gabrielle Lyon : 1405

    27.1.2026 | 1 t. 2 min.
    Your butt is not about aesthetics. It is a longevity organ that directly impacts metabolism, brain optimization, resilience, and how long you stay strong as you age. In this episode, you’ll learn why strength training and protein intake matter more than body fat percentage, how mitochondria drive human performance and recovery, and why building muscle protects your brain, stabilizes mood, and supports long-term longevity. This conversation reframes biohacking, anti-aging, and health from weight loss to muscle span, the length of time you live with strong, functional skeletal muscle.

    Watch this episode on YouTube for the full video experience:
    https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey sits down with Gabrielle Lyon, an accomplished physician and New York Times bestselling author of Forever Strong: A New, Science-Based Strategy for Aging Well, and author of the upcoming The Forever Strong Playbook, releasing January 27, 2026. Dr. Lyon pioneered the Muscle-Centric Medicine® approach, which places muscle at the center of disease prevention, metabolic health, and true vitality. She has trained elite athletes, military operatives, and public figures, while also living this philosophy at home as a mother of two with her husband, a retired Navy SEAL.

    Together, they break down why intermuscular fat may matter more than body fat percentage, how skeletal muscle drives insulin sensitivity and lowers inflammation, and why becoming physically stronger improves brain function and neuroplasticity. They explore protein needs across the lifespan, fasting, ketosis, carnivore-style nutrition, supplements, sleep optimization, and the real tradeoffs of GLP-1 drugs, including the risk of accelerated muscle loss if strength and protein are neglected. The conversation also covers mindset, hormesis, and why physical resilience creates emotional regulation and clearer decision-making in a world increasingly shaped by AI and convenience.

    This episode is essential listening for anyone serious about biohacking, hacking human performance, longevity, mitochondria, neuroplasticity, nootropics, metabolism, functional medicine, anti-aging strategies, supplements, and living Smarter Not Harder, ideally with a cup of Danger Coffee in hand.

    You’ll Learn:
    • Why your glutes and skeletal muscle are critical drivers of longevity and brain health
    • Why intermuscular fat can matter more than body fat percentage for metabolic dysfunction
    • How strength training improves neuroplasticity, cognition, and emotional resilience
    • Why protein needs increase with age and why outdated limits can hold you back
    • What GLP-1 drugs get right, where they fail, and how to protect muscle span
    • Why progressive stimulus beats lifting heavy for long-term strength and injury prevention
    • How sleep optimization and recovery support mitochondria and human performance
    • How building muscle creates clarity, resilience, and better decision-making

    Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

    Thank you to our sponsors!
    Quantum Upgrade | Support your brain, energy, focus, sleep, and recovery with Quantum Upgrade, a 24/7 streaming quantum energy service designed to work continuously in the background. Try it free for 15 days with no credit card required: https://quantumupgrade.io/DAVE
    Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave
    BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
    KillSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com and use code DAVE for 20% off.

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: muscle longevity organ, glutes brain health, strength training longevity podcast, muscle span aging, intermuscular fat metabolism, IMAT insulin resistance, skeletal muscle brain function, neuroplasticity strength training, protein intake aging, high protein diet longevity, metabolism muscle health, mitochondria muscle brain, muscle centric medicine podcast, gabrielle lyon podcast, forever strong playbook, women strength training longevity, GLP-1 muscle loss, sarcopenia aging prevention, resistance training brain health, sleep optimization muscle recovery, fasting ketosis muscle health, carnivore diet muscle metabolism, functional medicine muscle health, biohacking strength longevity, human performance muscle, anti-aging strength training, supplements muscle recovery, progressive stimulus training, blood flow restriction training, muscle resilience mindset

    Resources:
    • Get Gabrielle’s NEW book The Forever Strong Playbook: https://drgabriellelyon.com/playbook/
    • Gabrielle’s Website: https://drgabriellelyon.com/
    • Follow Gabrielle’s Instagram: https://www.instagram.com/drgabriellelyon/
    • Gabrielles Youtube: https://www.youtube.com/@DrGabrielleLyon
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Upgrade Collective: https://www.ourupgradecollective.com
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    0:00 – Introduction
    1:01 – The Playbook vs Workbook
    3:47 – Protein & Metabolic Health
    6:21 – Mindset & Negativity
    7:20 – Histamines & Hot Flashes
    10:49 – Women & Strength Training
    13:40 – Connective Tissue & EDS
    16:15 – Muscle Span & Aging
    19:41 – Training for Kids
    21:55 – Pain Cave & Discomfort
    25:25 – Emotional Regulation
    29:46 – Resilience & Dating
    32:11 – Building Friction & Discernment
    35:47 – Self-Denial vs Awareness
    41:03 – Mitochondria & Energy
    42:46 – Bigger Booty, Bigger Brain
    44:52 – Body Fat vs IMAT
    49:01 – Measuring Muscle Health
    52:08 – GLP-1s & Muscle Loss
    56:12 – Protein Absorption Myths
    59:30 – mTOR & Protein
    1:01:29 – Closing Thoughts
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404

    25.1.2026 | 22 min.
    Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.

    In this video, I explain how appetite is actually regulated, why synthetic shortcuts often create new problems over time, and what has quietly shut down the body’s natural satiety signals for so many people.

    Once you understand the pathway drugs are trying to imitate, the question stops being “how do I eat less?” and becomes “why was my body blocked from doing this in the first place?”

    This is about restoring a system, not overpowering it.

    Chapters
    0:00 - Introduction: Your Body’s Natural Ozempic
    0:53 - Hunger Is a Hormone Problem
    5:08 - How to Fix Your Hormone Signals
    7:28 - Why Ozempic Often Backfires
    10:54 - The Resistant Starch Solution
    15:03 - How to Use Resistant Starch
    18:12 - Rebuilding Your Gut Environment
    19:31 - Lifestyle Support for Gut Health

    Resources:
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Upgrade Collective: https://www.ourupgradecollective.com
    • Upgrade Labs: https://upgradelabs.com
    • 40 Years of Zen: https://40yearsofzen.com

    Connect with Dave Asprey!
    Website: https://daveasprey.com
    TikTok: https://www.tiktok.com/@daveaspreyofficial
    Instagram: https://www.instagram.com/dave.asprey/
    Facebook: https://www.facebook.com/Daveaspreyofficial/
    X: https://x.com/daveasprey
    YouTube: https://www.youtube.com/c/daveaspreybpr

    The Human Upgrade Podcast:
    Instagram: https://www.instagram.com/TheHumanUpgradePodcast/
    Facebook: https://m.facebook.com/Thehumanupgrade/
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    Biohacking News Weekly Update : 1403

    23.1.2026 | 9 min.
    This episode covers:

    • Real Food Reset in U.S. Dietary Policy
    The new Dietary Guidelines for Americans 2025–2030 put real food back at the center of U.S. nutrition policy and take a direct swing at ultra processed foods, added sugar, and sugary drinks. Dave breaks down why this matters beyond personal dieting: these guidelines influence school meals, SNAP and WIC, federal feeding programs, and they shape what eventually shows up on labels and in public institutions. He also shares how biohackers can use this shift as leverage to push for better food environments in schools, workplaces, and hospitals.
    -Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/07/kennedy-rollins-unveil-historic-reset-us-nutrition-policy-put-real-food-back-center-health

    • Drug Combo Extends Lifespan of Frail Old Mice by 73%
    A new aging study found that combining oxytocin with a compound called A5i extended the remaining lifespan of frail elderly male mice by 73%, while also improving function and tissue health. Dave explains why this is a big signal for the future of longevity medicine: stacking targeted interventions can outperform single compounds, especially when you start late in life. He also explains what to do with the idea right now: stop building random “everything stacks” and start thinking in phases, tracking outcomes, and waiting for real human combo data.
    -Source: https://www.futura-sciences.com/en/study-finds-drug-combo-could-slow-aging-and-increase-lifespan-by-73_23229/

    • ChatGPT Health Turns Your Data Into a Health OS
    OpenAI launched ChatGPT Health, a dedicated health experience that lets you securely connect medical records and wellness apps like Apple Health and MyFitnessPal, so you can summarize visits, interpret labs, and prepare better questions for your doctor. Dave explains why this is a turning point for quantified self and protocol building: it reduces the friction of pulling data from five different places, and it makes pattern-finding accessible to nontechnical people. He also shares how to use it like a pro: clean inputs, smarter questions, and better doctor conversations.
    -Source: https://openai.com/index/introducing-chatgpt-health/

    • Whole Milk Is Back in Schools
    The Whole Milk for Healthy Kids Act restores whole and reduced-fat milk options in schools, aligning school nutrition rules with the updated dietary guidelines that no longer treat full-fat dairy like a default villain. Dave breaks down why this matters for child healthspan: satiety and nutrient density drive behavior, learning, and metabolic stability. He also explains why this is a real-world policy experiment worth watching across school districts, and how it can open the door for bigger institutional upgrades like better protein and fewer ultra processed items.
    -Source: https://www.usda.gov/about-usda/news/press-releases/2026/01/14/whole-milk-back-president-trump-signs-whole-milk-healthy-kids-act

    • Tirzepatide Trial Targets Biological Age With Aging Clocks
    A registered clinical trial titled Tirzepatide to Slow Biological Aging is using multiple DNA methylation aging clocks as primary endpoints, along with functional metrics like grip strength and a 6-minute walk test. Dave explains why this is a big maturity step for longevity science: instead of assuming metabolic improvement equals slower aging, this study is measuring biological age directly, across multiple clocks, with performance outcomes. He also shares the practical lesson for biohackers: stop relying on one favorite metric and start thinking in panels, function, and durability of results.
    -Source: https://clinicaltrials.gov/study/NCT07220473

    All source links provided for direct access to the original research and reporting.



    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want practical strategies rooted in cutting-edge science. Host Dave Asprey translates emerging research into actionable upgrades for your biology, from metabolism and food policy to AI-driven tracking, institutional nutrition, and biological aging measurement.

    New episodes every Tuesday, Thursday, Friday, and Sunday.

    Keywords: Dietary Guidelines for Americans 2025-2030, real food policy reset, ultra processed foods policy, added sugar limits, sugary drinks guidelines, school lunch nutrition policy, SNAP WIC nutrition impact, USDA HHS dietary guidelines 2026, whole food protein guidelines, full fat dairy guidelines, oxytocin aging study, A5i lifespan extension, frail elderly mice lifespan 73 percent, combination longevity therapies, aging intervention synergy, staged longevity protocols, functional aging biomarkers, ChatGPT Health launch, OpenAI health records AI, Apple Health ChatGPT integration, MyFitnessPal ChatGPT integration, AI lab interpretation, AI doctor visit summary, quantified self AI tools, Whole Milk for Healthy Kids Act, whole milk back in schools, school dairy policy change, child satiety nutrition, school meal regulations USDA, tirzepatide biological aging trial, GLP-1 GIP longevity, epigenetic aging clocks trial, DNAmAge PhenoAge GrimAge DunedinPACE, grip strength aging endpoint, 6 minute walk aging endpoint, biological age measurement, longevity clinical trial endpoints, biohacking news update, longevity policy shifts, metabolic health upgrades

    Thank you to our sponsors!
    -BEYOND Conference 2026 | Register now at https://beyondconference.com/
    -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off

    Resources:
    • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Upgrade Collective: https://www.ourupgradecollective.com
    • Upgrade Labs: https://upgradelabs.com
    • 40 Years of Zen: https://40yearsofzen.com

    Timestamps:
    0:00 - Intro
    0:19 - New Dietary Guidelines
    2:09 - Longevity Research Breakthrough
    3:41 - ChatGPT Health Launch
    5:10 - Whole Milk Returns to Schools
    6:29 - GLP-1 Aging Trial
    7:34 - Weekly Upgrade Protocol
    9:09 - Outro
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
  • The Human Upgrade: Biohacking for Longevity & Performance

    This Brain Trick Feels Like Cheating (Do THIS) : 1402

    22.1.2026 | 1 t. 13 min.
    Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair.

    Watch this episode on YouTube for the full video experience:
    https://www.youtube.com/@DaveAspreyBPR

    Host Dave Asprey is joined by Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work focuses on the intersection of neurology, nutrition, metabolism, and brain health. A Fellow of the American College of Nutrition and member of the Editorial Board of the Journal of Alzheimer’s Disease, Dr. Perlmutter brings decades of clinical and research experience to this conversation on how inflammation and mitochondrial function shape the brain across the lifespan.

    Together, they explore how microglial cells shift their behavior based on metabolic conditions, and how those shifts influence neurodegeneration, emotional regulation, impulse control, and cognitive performance. The discussion covers real-world inputs that shape these systems, including sleep optimization, fasting, ketosis, glucose regulation, gut signaling, environmental toxins, and tools referenced in the episode such as red and infrared light, 40 Hz light and sound, hyperbaric oxygen, lithium, nicotine, supplements, nootropics, GLP-1 agonists, and dietary approaches like carnivore and ketosis. The conversation connects brain biology to lived experience, showing how metabolism influences behavior, decision making, and long-term human performance through a Smarter Not Harder lens.

    You’ll Learn:
    • How microglia shift between supportive and destructive states and why metabolism drives that change
    • How mitochondrial function inside immune cells influences inflammation and brain resilience
    • How inflammation affects the prefrontal cortex, impulse control, and reward-driven behavior
    • What the episode says about GLP-1 agonists and behavior changes like reduced cravings and gambling
    • How gut-derived signaling and short-chain fatty acid balance (butyrate vs propionate) relates to brain function
    • How tools like red and infrared light, hyperbaric oxygen, and 40 Hz light and sound connect to microglia
    • The lifestyle levers discussed in the episode: sleep optimization, fasting, ketosis, glucose control, and toxin reduction
    • The compounds mentioned, including lithium, nicotine, urolithin A, CoQ10, rosmarinic acid, and dihydromyricetin

    Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

    Thank you to our sponsors!

    KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off.
    BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.
    Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide
    Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE

    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

    Keywords: microglia brain health, brain immune system mitochondria, neuroinflammation podcast, mitochondrial dysfunction brain, david perlmutter podcast, dr david perlmutterneurologist, grain brain author podcast, alzheimers brain metabolism, parkinsons microglia, autism brain inflammation, gut brain immune signaling, short chain fatty acids brain, butyrate propionate brain, glp-1 brain behavior, glp-1 addiction research, red light therapy brain, infrared light mitochondria brain, 40 hz light sound brain, hyperbaric oxygen brain health, lithium microglia brain

    Resources:
    • Learn More About Dr. Perlmutter at: https://drperlmutter.com/
    • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
    • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/
    • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
    • Danger Coffee: https://dangercoffee.com/discount/dave15
    • My Daily Supplements: SuppGrade Labs (15% Off)
    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
    • Dave Asprey’s BEYOND Conference: https://beyondconference.com
    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
    • Upgrade Collective: https://www.ourupgradecollective.com
    • Upgrade Labs: https://upgradelabs.com

    Timestamps:
    0:00 - Introduction
    1:45 - Autism Spectrum
    4:38 - Alzheimer’s & Beta Amyloid
    7:02 - Brain Immune Cells
    8:06 - GLP-1 & Parkinson’s
    10:44 - M1 vs M2 Microglia
    13:08 - Pharmaceutical Microdosing
    15:51 - Gene Therapy
    19:09 - Mold & Toxins
    21:58 - Environmental Pollution
    26:05 - MPTP Discovery
    29:07 - Healing Interventions
    31:39 - Light & Sound Therapy
    36:35 - Mitochondrial Function
    44:57 - Inflammation & Prefrontal Cortex
    48:00 - GLP-1 Global Impact
    52:11 - Mitochondrial Community
    56:05 - Consciousness & The Field
    1:00:00 - Psychedelics
    1:01:59 - Love & Judgment
    1:06:35 - Death & Knowing
    1:09:06 - Heart-Brain Connection
    1:11:06 - Closing Thoughts
    See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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Om The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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