JAMA Clinical Reviews

Childhood obesity affects approximately 15% of children aged 2 to 12 and is associated with adverse health outcomes in adulthood. Author Claudia K. Fox, MD, MPH, of the University of Minnesota Medical School joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss epidemiology, diagnosis, and treatment of childhood obesity.

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Obesity in Children Aged 2 to 12 Years

Heart transplant for patients with advanced heart failure can lead to improved survival and quality of life. Author JoAnne Lindenfeld, MD, of Vanderbilt University joins JAMA Associate Editor David Simel, MD, MHS, to discuss indications, transplant evaluation, management after transplant, long-term complications, and survival.

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Heart Transplant for Advanced Heart Failure

Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Author Tom Scammell, MD, of Harvard Medical School joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the etiology, clinical presentation, diagnostic evaluation, and treatment of narcolepsy.

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The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

Respiratory virus vaccine effectiveness and safety for influenza, RSV, and COVID-19 are reviewed, including new evidence, risks, and recommendations. JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks with Rochelle Walensky, MD, MPH, professor of medicine at Harvard Medical School and former CDC Director, about vaccine data, public trust, and the 2026 respiratory virus season.

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RSV Immunization Effectiveness and Safety for the 2026-2027 Respiratory Season
Influenza Vaccine Effectiveness and Safety for the 2026-2027 Respiratory Season
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Cancer vaccines stimulate immune cells to recognize proteins or mutations found on or within cancer cells, facilitating destruction of cancer cells. Several vaccines are approved and others are in development for cancer treatment. Author Nora Disis, MD, JAMA Deputy Editor and Editor in Chief of JAMA Oncology, discusses cancer vaccines and more with JAMA Deputy Editor Mary McDermott, MD.

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Vaccines for Cancer