In this episode, we explore zoonotic diseases and their growing impact on global health. Professor Clare Bryant, sheds light on strategies to vaccinate animals to prevent pathogen transmission into humans. We also delve into the historical context of the disease, the role of vaccines, and the importance of coordinated public health.Whether you're a public health professional or simply curious about emerging infectious diseases, this episode offers a comprehensive look at the science, challenges, and solutions surrounding zoonotic diseases.
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105. What is pain?
Pain. It comes in many forms: physical and emotional. But do we really understand it?This episode will attempt to answer fundamental questions about what pain is, how it is experienced, and why it is such a critical aspect of human existence. We speak with Prof Jeff Mogil to discuss sex differences in pain. His work has been influential in promoting the inclusion of both sexes in pain research, ensuring that treatments and pain management strategies are more effective for everyone. We are also joined by Steve Ruston, CEO of Persica, to discuss non-opioid intradiscal injection to treat chronic low back pain caused by bacterial infection. Show notesNanoparticle gel could help save degraded coral reefsPlants struggled for millions of years after the world's worst climate catastrophe
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104. Vaccines: Inverse v traditional
Today, we're diving into a topic that's not just reshaping the world of vaccines—it's flipping it on its head. We're exploring the cutting-edge realm of inverse vaccines with Prof Lawrence Steinman and how they're revolutionizing the approach to treating autoimmune diseases. Plus, we'll chat with CancerVax, who are using the immune system in a radically different way, aiming to make it attack cancer cells just like it would fight off a virus like measles.
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103. How space impacts the body
Ever wonder what happens to your body when you leave Earth behind? In this gravity-defying episode, we launch into the weird, wild world of human biology in space. From the first C. elegans in space to the NASA Twins Study to future deep space missions, we have a lot to discuss. Strap in as we float through the science of space adaptation. Spoiler: space may teach us about our Earth-bound health. Show notes• Deane, Colleen S, et al. (2023) Comparative analysis of muscle atrophy during spaceflight, nutritional deficiency and disuse in the nematode caenorhabditis elegans. International Journal of Molecular Sciences, 24 (16), [12640]. • Francine E. Garrett-Bakelman et al. (2019) The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science, 364 (8650).• Bokhari RS, et al. (2022) Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst), 35 (105-112).• Glavin, D.P., et al. (2025) Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu. Nat Astron 9 (199–210).• Eyting, M., et al. (2025) A natural experiment on the effect of herpes zoster vaccination on dementia. Nature.
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102. Fighting diabetes differently
What's new with insulin? Jeppe Sturis and his team at Novo Nordisk have a new hypothesis. They challenge the long-held belief that insulin resistance comes from faulty tissues, suggesting instead that the real culprit is insulin breaking down before it even reaches its target. This fresh perspective could reshape how we fight diabetes.We will also hear from Diamyd Medical’s advancing research on antigen-specific immunotherapy which could change the game by protecting insulin-producing cells and slowing the progression of Type 1 diabetes.
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